PrecisionBIOME® for
Otolaryngology
PrecisionBIOME® for Otolaryngology (Ear, Nose, Throat)
Benefit from comprehensive and accurate pathogen detection for acute and chronic ENT infections with PrecisionBIOME®.
Our easy-to-interpret report offers microbial quantification, listing pathogens in order of most to least abundant with estimated cell counts. The same report also delivers information on pathogen-specific antibiotic susceptibilities for targeted, effective treatments and good antibiotic stewardship.
Contact Us to Learn More About PrecisionBIOME®
One test can identify over 700 of the most clinically relevant species
– Actinomyces species
– Anaerococcus species
– Acinetobacter baumanii/ iwoffii
– Actinomyces species
– Anaerococcus species
– Bacillus anthracis
– Bacteroides species
– Bordetella species
– Borrelia species
– Brevibacterium species
– Brucella species
– Burkholderia species
– Campylobacter species
– Chlamydia pneumoniae
– Citrobacter species
– Corynebacterium species
– Dialister species
– Eikenella corrodens
– Enterobacter species
– Escherichia coli
– Finegoldia magna
– Fusobacterium species
– Gemella species
– Haemophilus influenzae
– Klebsiella species
– Leptospira species
– Moraxella species
– Morganella morganii
– Mycobacterium species
– Mycoplasma pneumoniae
– Neisseria species
– Nocardia species
– Parvimonas species
– Peptoniphilus species
– Prevotella species
– Pseudomonas aeruginosa
– Raoultella species
– Rothia species
– Salmonella enterica
– Schaalia species
– Serratia marcescens
– Staphylococcus aureus
– S. maltophilia
– Streptococcus species
– Streptomyces species
– Veillonella parvula
– Weeksella virosa
– Altenaria species
– Aspergillus species
– Acremonium species
– Altenaria species
– Aspergillus species
– Aureobasidium melanogenum/pullulans Bipolaris species
– Candida species
– Chaetomium species
– Conidiobolus species
– Cryptococcus species
– Cunninghamella species
– Curvularia species
– Fusarium species
– Humicola nigrescens
– Lichtheimia species
– Microascus species
– Mucor species
– Naganishia species
– Penicillium species
– Pneumocystis carinii/jirovecii
– Rhizopus species
– Rhodotorula species
– Saksenaea species
– Talaromyces marneffei/purpureogenus
– Trichoderma species
– Trichosporon species
Get the Data You Need to Treat Acute and Chronic ENT Infections Quickly and Effectively
Ear Infections can occur in both children and adults but are most common in children under 15 years of age. They are one of the main reasons for doctor’s visits and the leading cause of antibiotic prescriptions.
Otitis media is a common type of ear infection characterized by inflammation of the middle ear with an accumulation of fluid behind the eardrum, often leading to swelling, redness, and pain.
Otitis externa, also known as swimmer’s ear, consists of infection and inflammation of the outer ear canal accompanied by pain, redness, and tenderness with occasional purulent exudates.
Sinusitis is among the most common disorder of the nasal cavity with nearly 35 million patients receiving a diagnosis for this disease each year in the US. It occurs when the nasal passage becomes swollen and inflamed leading to difficulty breathing, congestion, pressure, and pain around the eyes, cheeks, or forehead.
Tonsillitis is an infection of the tonsils leading to inflammation, difficulty swallowing, fever, and sore throat. Tonsils are prone to infections since they are the immune system’s first line of defense against pathogens that enter the body through the mouth.
If left untreated or unresolved, these conditions can become chronic, and doctors may recur to more invasive surgical procedures to lessen the symptoms.
Knowing what is causing these infections early on can greatly aid doctors in designing targeted, more successful treatments that can help resolve these infections faster and with a lower rate of recurrence. Conventional culture methods lack the sensitivity and specificity needed to detect certain pathogens that may be causing these infections as only a small fraction of these microbes can grow under standard laboratory conditions.
What Otolaryngologists Say
Dr. Charles K. Oh, MD, Tustin ENT, Tustin, CA
As patients become more informed, they appreciate that we can offer the newest techniques to use gene sequencing to identify pathogens and antibiotic resistance. The faster turnaround time allows me to use this microbial data for directed therapy in ENT.
Dr. Michael Kao, MD, Greater OC ENT, Fullerton, CA
PrecisionBIOME® ENT Case Studies
Case 1
A 52-year-old female patient received multiple rounds of antibiotic treatment for a persistent middle ear infection. Since the patient was unresponsive to the prescribed treatments, a PrecisionBIOME® NGS Microbial test was ordered to ID possible causative agents of the infection.
Test results showed the presence of 3 fungal pathogens in the ear at high cell counts, with no bacterial pathogens detected. The doctor changed the anti-bacterial treatment to an anti-fungal therapy, and the patient’s condition resolved in only one week.
Case 2
A 76-year-old male patient suffering from chronic sinusitis benefited from the comprehensive bacterial data found in the PrecisionBIOME® report.
Rhinosinusitis can be the result of a polymicrobial infection with multiple pathogenic species contributing to the condition. While standard-of-care cultures can often only identify just one or two bacterial species in a sinus infection, the PrecisionBIOME® NGS test can detect and ID far more of them simultaneously. The test also provided pathogen-specific antibiotic susceptibility for a more thorough, effective antibiotic treatment.
The patient recovered in only 2 weeks with no symptom recurrence.
Disclaimers
Test development and performance characteristics were as determined by Pangea Laboratory, LLC.
Detection of most commonly acquired resistance genes and mutations that confer resistance to the different antibiotic classes including Carbapenems, Cephalosporins, Penicillins, Aminoglycosides, Fluoroquinolones, Macrolides, Glycopeptides, Tetracyclines, Sulfonamides, and Rifamycins